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Anti-Phospho-BRCA1-S988PolyclonalAntibody-一抗-抗體-蛋白與免疫

2023-10-29

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Anti-Phospho-BRCA1-S988 Polyclonal Antibody品牌：solarbio | 貨號：K006215P

英文名稱	Anti-Phospho-BRCA1-S988 Polyclonal Antibody
宿主	Rabbit
別名	BRCAI;BRCC1;BROVCA1;FANCS;IRIS;PNCA4;PPP1R53;PSCP;RNF53
應(yīng)用	WB IF
稀釋比例	WB 1:500-2000. IF 1:50-200.
交叉反應(yīng)	Human
蛋白分子量	208kDa
Gene ID	672
保存	Store at -20°C. Avoid freeze / thaw cycles.
儲存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
純化方法	Affinity purification
亞型	IgG
免疫原	A phospho specific peptide corresponding to residues surrounding S988 of human BRCA1
性狀	液體
Public Immunogen Range	A phospho specific peptide corresponding to residues surrounding S988 of human BRCA1
Subcellular Locations	Chromosome Cytoplasm Cytoplasm Nucleus
Swiss Prot	P38398
克隆類型	Polyclonal Antibody
背景資料	This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

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