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Anti-Phospho-MAPK14-Y322PolyclonalAntibody-一抗-抗體-蛋白與免疫

2023-10-29

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Anti-Phospho-MAPK14-Y322 Polyclonal Antibody品牌:solarbio | 貨號(hào):K006186P

英文名稱(chēng)Anti-Phospho-MAPK14-Y322 Polyclonal Antibody
宿主Rabbit
別名CSBP;CSBP1;CSBP2;CSPB1;EXIP;Mxi2;PRKM14;PRKM15;RK;SAPK2A;p38;p38ALPHA
應(yīng)用WB IF
稀釋比例WB 1:500-2000. IF 1:50-200.
交叉反應(yīng) Human Mouse
蛋白分子量41kDa
Gene ID1432
保存Store at -20°C. Avoid freeze / thaw cycles.
儲(chǔ)存液Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原A phospho specific peptide corresponding to residues surrounding Y322 of human MAPK14
性狀液體
Public Immunogen RangeA phospho specific peptide corresponding to residues surrounding Y322 of human MAPK14
Subcellular LocationsCytoplasm Nucleus
Swiss ProtQ16539
克隆類(lèi)型 Polyclonal Antibody
背景資料The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

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