Anti-MC1RPolyclonalAntibody-一抗-抗體-蛋白與免疫-耗材-Bio-Rad伯樂官網(wǎng) |伯樂授權(quán)代理 |伯樂ddPCR| 伯樂Aminex| 伯樂層析填料色譜柱

Anti-MC1RPolyclonalAntibody-一抗-抗體-蛋白與免疫

2023-10-29

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Anti-MC1R Polyclonal Antibody品牌：solarbio | 貨號(hào)：K007529P

英文名稱	Anti-MC1R Polyclonal Antibody
宿主	Rabbit
別名	CMM5;MSH-R;SHEP2
應(yīng)用	WB
稀釋比例	WB 1:500-2000.
交叉反應(yīng)	Human Mouse
蛋白分子量	35kDa
Gene ID	4157
保存	Store at -20°C. Avoid freeze / thaw cycles.
儲(chǔ)存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法	Affinity purification
亞型	IgG
免疫原	A synthetic peptide of human MC1R
性狀	液體
Public Immunogen Range	A synthetic peptide of human MC1R
Swiss Prot	Q01726
克隆類型	Polyclonal Antibody
背景資料	This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.

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