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Anti-PDK3PolyclonalAntibody-一抗-抗體-蛋白與免疫

2023-10-29

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Anti-PDK3 Polyclonal Antibody品牌：solarbio | 貨號：K005628P

英文名稱Anti-PDK3 Polyclonal Antibody
宿主Rabbit
別名CMTX6;GS1-358P8.4
應(yīng)用WB IHC
稀釋比例WB 1:500-2000. IHC 1:50-100.
交叉反應(yīng) Human Mouse Rat
蛋白分子量47kDa
Gene ID5165
保存Store at -20°C. Avoid freeze / thaw cycles.
儲存液Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原Recombinant protein of human PDK3
性狀液體
Public Immunogen RangeRecombinant protein of human PDK3
Subcellular LocationsMitochondrion matrix
Swiss ProtQ15120
克隆類型 Polyclonal Antibody
背景資料The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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