Anti-SMAD2PolyclonalAntibody-一抗-抗體-蛋白與免疫-耗材-Bio-Rad伯樂(lè)官網(wǎng) |伯樂(lè)授權(quán)代理 |伯樂(lè)ddPCR| 伯樂(lè)Aminex| 伯樂(lè)層析填料色譜柱

Anti-SMAD2PolyclonalAntibody-一抗-抗體-蛋白與免疫

2023-10-29

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Anti-SMAD2 Polyclonal Antibody品牌：solarbio | 貨號(hào)：K005398P

英文名稱	Anti-SMAD2 Polyclonal Antibody
宿主	Rabbit
別名	JV18;JV18-1;MADH2;MADR2;hMAD-2;hSMAD2
應(yīng)用	WB IHC IF
稀釋比例	WB 1:500-2000. IHC 1:50-200. IF 1:50-200.
交叉反應(yīng)	Human Mouse Rat
蛋白分子量	52kDa
Gene ID	4087
保存	Store at -20°C. Avoid freeze / thaw cycles.
儲(chǔ)存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
純化方法	Affinity purification
亞型	IgG
免疫原	A synthetic peptide of human SMAD2
性狀	液體
Public Immunogen Range	A synthetic peptide of human SMAD2
Subcellular Locations	Cytoplasm Nucleus
Swiss Prot	Q15796
克隆類型	Polyclonal Antibody
背景資料	The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene ‘mothers against decapentaplegic’ (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

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Anti-SMAD2PolyclonalAntibody-一抗-抗體-蛋白與免疫

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