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Anti-SART1PolyclonalAntibody-一抗-抗體-蛋白與免疫

2023-10-29

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Anti-SART1 Polyclonal Antibody品牌:solarbio | 貨號(hào):K005919P

英文名稱Anti-SART1 Polyclonal Antibody
宿主Rabbit
別名Ara1;HOMS1;SART1259;SNRNP110;Snu66
應(yīng)用WB IP
稀釋比例WB 1:500-2000. IP 1:20-50.
交叉反應(yīng) Human Mouse Rat
蛋白分子量90kDa
Gene ID9092
保存Store at -20°C. Avoid freeze / thaw cycles.
儲(chǔ)存液Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原Recombinant protein of human SART1
性狀液體
Public Immunogen RangeRecombinant protein of human SART1
Subcellular LocationsNucleus
Swiss ProtO43290
克隆類型 Polyclonal Antibody
背景資料This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.

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