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Anti-NPRL2PolyclonalAntibody-一抗-抗體-蛋白與免疫

2023-10-29

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Anti-NPRL2 Polyclonal Antibody品牌：solarbio | 貨號：K007781P

英文名稱Anti-NPRL2 Polyclonal Antibody
宿主Rabbit
別名NPR2;NPR2L;TUSC4
應(yīng)用WB IHC
稀釋比例WB 1:200-1000. IHC 1:50-200.
交叉反應(yīng) Human Mouse
蛋白分子量44kDa
Gene ID10641
保存Store at -20°C. Avoid freeze / thaw cycles.
儲(chǔ)存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原A synthetic peptide of human NPRL2
性狀液體
Public Immunogen RangeA synthetic peptide of human NPRL2
Subcellular LocationsCytoplasm
Swiss ProtQ8WTW4
克隆類型 Polyclonal Antibody
背景資料NPRL2, also known as TUSC4 (tumor suppressor candidate 4), is a 380 amino acid protein that contains a bipartite nuclear localization signal and a granulin protein-binding domain. It is highly expressed in skeletal muscle, followed by brain, liver and pancreas, with lower expression in lung, kidney, placenta and heart. NPRL2 is also expressed in most lung cancer cell lines and may be involved in tumor suppression. NPRL2 may play a role in mismatch repair, cell cycle checkpoint signaling and activation of apoptotic pathways. It may also enhance the therapeutic efficacy of chemotherapy drugs such as cis-platin by resensitizing patients resistant to cisplatin treatment. The gene encoding NPRL2 is conserved between species and is expressed as two isoforms due to alternative splicing events.

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