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Anti-CCM2PolyclonalAntibody-一抗-抗體-蛋白與免疫

2023-10-29

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Anti-CCM2 Polyclonal Antibody品牌：solarbio | 貨號：K004601P

英文名稱Anti-CCM2 Polyclonal Antibody
宿主Rabbit
別名C7orf22;OSM;PP10187
應(yīng)用WB IHC
稀釋比例WB 1:500-2000. IHC 1:50-200.
交叉反應(yīng) Human Mouse Rat
蛋白分子量49kDa
Gene ID83605
保存Store at -20°C. Avoid freeze / thaw cycles.
儲存液Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原Recombinant protein of human CCM2
性狀液體
Public Immunogen RangeRecombinant protein of human CCM2
Subcellular LocationsCytoplasm
Swiss ProtQ9BSQ5
克隆類型 Polyclonal Antibody
背景資料This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.

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