Anti-EGLN3PolyclonalAntibody-一抗-抗體-蛋白與免疫-耗材-Bio-Rad伯樂官網(wǎng) |伯樂授權(quán)代理 |伯樂ddPCR| 伯樂Aminex| 伯樂層析填料色譜柱

Anti-EGLN3PolyclonalAntibody-一抗-抗體-蛋白與免疫

2023-10-29

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Anti-EGLN3 Polyclonal Antibody品牌：solarbio | 貨號(hào)：K008225P

英文名稱	Anti-EGLN3 Polyclonal Antibody
宿主	Rabbit
別名	PHD3;HIFPH3;HIFP4H3
應(yīng)用	WB
稀釋比例	WB 1:200-1000.
交叉反應(yīng)	Human Mouse Rat
蛋白分子量	27kDa
Gene ID	112399
保存	Store at -20°C. Avoid freeze / thaw cycles.
儲(chǔ)存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法	Affinity purification
亞型	IgG
免疫原	Recombinant protein of human EGLN3
性狀	液體
Public Immunogen Range	Recombinant protein of human EGLN3
Swiss Prot	Q9H6Z9
克隆類型	Polyclonal Antibody
背景資料	Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM in hypoxia, limiting glycolysis. Under normoxia, hydroxylates and regulates the stability of ADRB2. Regulator of cardiomyocyte and neuronal apoptosis.

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Anti-EGLN3PolyclonalAntibody-一抗-抗體-蛋白與免疫

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