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Anti-SPATA13PolyclonalAntibody-一抗-抗體-蛋白與免疫

2023-10-29

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Anti-SPATA13 Polyclonal Antibody品牌：solarbio | 貨號：K006838P

英文名稱Anti-SPATA13 Polyclonal Antibody
宿主Rabbit
別名ASEF2;ARHGEF29;RP11-307N16.3
應(yīng)用WB IHC
稀釋比例WB 1:200-1000. IHC 1:25-100.
交叉反應(yīng) Human Mouse
蛋白分子量75kDa
Gene ID221178
保存Store at -20°C. Avoid freeze / thaw cycles.
儲存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原Recombinant protein of human SPATA13
性狀液體
Public Immunogen RangeRecombinant protein of human SPATA13
Subcellular LocationsCytoplasm
Swiss ProtQ96N96
克隆類型 Polyclonal Antibody
背景資料Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. Both the ABR and the SH3 domains contribute to maintaining the protein in an inhibited conformation by associating with the C-terminal tail. Binding of these domains to the C-terminal tail inhibits the activity of the protein by blocking a region that is required for its GEF activity.

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