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Anti-HRASPolyclonalAntibody-一抗-抗體-蛋白與免疫

2023-10-29

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Anti-HRAS Polyclonal Antibody品牌:solarbio | 貨號(hào):K007381P

英文名稱Anti-HRAS Polyclonal Antibody
宿主Rabbit
別名CTLO;HAMSV;HRAS1;RASH1;p21ras;C-H-RAS;H-RASIDX;C-BAS/HAS;C-HA-RAS1
應(yīng)用WB IHC
稀釋比例WB 1:500-2000. IHC 1:25-50.
交叉反應(yīng) Human Mouse Rat
蛋白分子量21kDa
Gene ID3265
保存Store at -20°C. Avoid freeze / thaw cycles.
儲(chǔ)存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原A synthetic peptide of human HRAS
性狀液體
Public Immunogen RangeA synthetic peptide of human HRAS
Subcellular LocationsCytoplasm
Swiss ProtP01112
克隆類(lèi)型 Polyclonal Antibody
背景資料This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.

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