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Anti-DFFAPolyclonalAntibody-一抗-抗體-蛋白與免疫

2023-10-29

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Anti-DFFA Polyclonal Antibody品牌:solarbio | 貨號:K006765P

英文名稱Anti-DFFA Polyclonal Antibody
宿主Rabbit
別名DFF1;ICAD;DFF-45
應用WB IHC
稀釋比例WB 1:500-2000. IHC 1:30-150.
交叉反應 Human
蛋白分子量37kDa
Gene ID1676
保存Store at -20°C. Avoid freeze / thaw cycles.
儲存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原Recombinant protein of human DFFA
性狀液體
Public Immunogen RangeRecombinant protein of human DFFA
Subcellular LocationsNucleus Cytoplasm
Swiss ProtO00273
克隆類型 Polyclonal Antibody
背景資料Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

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