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Anti-BBS10PolyclonalAntibody-一抗-抗體-蛋白與免疫

2023-10-29

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Anti-BBS10 Polyclonal Antibody品牌:solarbio | 貨號(hào):K005974P

英文名稱(chēng)Anti-BBS10 Polyclonal Antibody
宿主Rabbit
別名C12orf58
應(yīng)用WB
稀釋比例WB 1:200-3000.
交叉反應(yīng) Human Mouse
蛋白分子量81kDa
Gene ID79738
保存Store at -20°C. Avoid freeze / thaw cycles.
儲(chǔ)存液Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原Recombinant protein of human BBS10
性狀液體
Public Immunogen RangeRecombinant protein of human BBS10
Subcellular LocationsCell projection cilium
Swiss ProtQ8TAM1
克隆類(lèi)型 Polyclonal Antibody
背景資料This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein’s expression impairs ciliogenesis in preadipocytes. Mutations in this gene cause Bardet-Biedl syndrome type 10.

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