Anti-GSTA2PolyclonalAntibody-一抗-抗體-蛋白與免疫
2023-10-29
平臺授權(quán)一級代理，咨詢微信：jinshanbio
Anti-GSTA2 Polyclonal Antibody品牌：solarbio | 貨號：K005386P| 英文名稱 | Anti-GSTA2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | GST2;GSTA2-2;GTA2;GTH2 |
| 應(yīng)用 | WB IHC |
| 稀釋比例 | WB 1:500-2000. IHC 1:50-200. |
| 交叉反應(yīng) | Human Mouse Rat |
| 蛋白分子量 | 26kDa |
| Gene ID | 2939 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | Recombinant protein of human GSTA2 |
| 性狀 | 液體 |
| Public Immunogen Range | Recombinant protein of human GSTA2 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | P09210 |
| 克隆類型 | Polyclonal Antibody |
| 背景資料 | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual’s susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. |
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