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Anti-TGFB2PolyclonalAntibody-一抗-抗體-蛋白與免疫

2023-10-29

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Anti-TGFB2 Polyclonal Antibody品牌:solarbio | 貨號:K003684P

英文名稱Anti-TGFB2 Polyclonal Antibody
宿主Rabbit
別名G-TSF;LDS4;TGF-beta2
應(yīng)用WB IF
稀釋比例WB 1:200-2000. IF 1:50-200.
交叉反應(yīng) Human MouseRat
蛋白分子量48kDa
Gene ID7042
保存Store at -20°C. Avoid freeze / thaw cycles.
儲存液Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原Recombinant Protein of human TGFB2
性狀液體
Public Immunogen RangeRecombinant Protein of human TGFB2
Subcellular LocationsSecreted
Swiss ProtP61812
克隆類型 Polyclonal Antibody
背景資料This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters’ anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing.

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