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Anti-Phospho-PRKACA-T197PolyclonalAntibody-一抗-抗體-蛋白與免疫

2023-10-29

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Anti-Phospho-PRKACA-T197 Polyclonal Antibody品牌：solarbio | 貨號：K006238P

英文名稱Anti-Phospho-PRKACA-T197 Polyclonal Antibody
宿主Rabbit
別名PKACA;PPNAD4
應(yīng)用WB
稀釋比例WB 1:500-2000.
交叉反應(yīng) Human Mouse Rat
蛋白分子量41kDa
Gene ID5566
保存Store at -20°C. Avoid freeze / thaw cycles.
儲存液Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原A phospho specific peptide corresponding to residues surrounding T197 of human PRKACA
性狀液體
Public Immunogen RangeA phospho specific peptide corresponding to residues surrounding T197 of human PRKACA
Subcellular LocationsCell membrane Cell projection Cytoplasm Lipid-anchor Membrane Mitochondrion Nucleus cilium flagellum
Swiss ProtP17612
克隆類型 Polyclonal Antibody
背景資料This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing’s syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms.

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