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Anti-CHRDL2PolyclonalAntibody-一抗-抗體-蛋白與免疫

2023-10-29

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Anti-CHRDL2 Polyclonal Antibody品牌：solarbio | 貨號：K007690P

英文名稱Anti-CHRDL2 Polyclonal Antibody
宿主Rabbit
別名BNF1;CHL2;FKSG37
應(yīng)用WB IHC
稀釋比例WB 1:500-2000. IHC 1:25-100.
交叉反應(yīng) Human
蛋白分子量48kDa
Gene ID25884
保存Store at -20°C. Avoid freeze / thaw cycles.
儲存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原A synthetic peptide of human CHRDL2
性狀液體
Public Immunogen RangeA synthetic peptide of human CHRDL2
Subcellular LocationsCytoplasm
Swiss ProtQ6WN34
克隆類型 Polyclonal Antibody
背景資料CHRDL2 (chordin-related protein 2), also known as BNF1 (breast tumor novel factor 1) or CHL2 (chordin-like 2), is a 429 amino acid protein that belongs to the chordin family of proteins. CHRDL2 contains three VWFC (von Willebrand Factor type C) domains and is predominantly expressed in uterus and moderately expressed in prostate, liver, ovary, heart and testis. Due to alternative splicing events, CHRDL2 exists as five isoforms, namely isoform I, isoform II, isoform VII, isoform VIII and isoform IX. Two of these isoforms are secreted, while the other three localize to the cytoplasm. Functioning as a BMP-binding inhibitor, CHRDL2 directly interacts with BMPs and blocks their binding to BMP receptors, thereby inhibiting BMP activity. In breast, lung and colon tumors, CHRDL2 expression is upregulated, suggesting a possible role in tumorigenesis.

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