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Anti-ACVR1PolyclonalAntibody-一抗-抗體-蛋白與免疫

2023-10-29

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Anti-ACVR1 Polyclonal Antibody品牌:solarbio | 貨號:K008353P

英文名稱Anti-ACVR1 Polyclonal Antibody
宿主Rabbit
別名FOP;ALK2;SKR1;TSRI;ACTRI;ACVR1A;ACVRLK2
應(yīng)用WB IHC
稀釋比例WB 1:500-2000. IHC 1:50-200.
交叉反應(yīng) Human Mouse Rat
蛋白分子量57kDa
Gene ID90
保存Store at -20°C. Avoid freeze / thaw cycles.
儲(chǔ)存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原Recombinant protein of human ACVR1
性狀液體
Public Immunogen RangeRecombinant protein of human ACVR1
Subcellular LocationsCytoplasm
Swiss ProtQ04771
克隆類型 Polyclonal Antibody
背景資料Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.

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