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Anti-SMAD4PolyclonalAntibody-一抗-抗體-蛋白與免疫

2023-10-29

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Anti-SMAD4 Polyclonal Antibody品牌：solarbio | 貨號：K106621P

英文名稱Anti-SMAD4 Polyclonal Antibody
宿主Rabbit
別名DPC4;hSMAD4;JIP;MAD homolog 4;MADH4;Mothers against DPP homolog 4;SMAD 4;SMAD family member 4;SMAD4
應用WB
稀釋比例WB 1:500-2000.
交叉反應 Human
蛋白分子量60kDa
Gene ID4089
保存Store at -20°C. Avoid freeze / thaw cycles.
儲存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原Recombinant protein of human SMAD4
性狀液體
Public Immunogen RangeRecombinant protein of human SMAD4
Subcellular LocationsCytoplasm Nucleus
Swiss ProtQ13485
克隆類型 Polyclonal Antibody
背景資料This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.

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