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Anti-MDM2PolyclonalAntibody-一抗-抗體-蛋白與免疫

2023-10-29

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Anti-MDM2 Polyclonal Antibody品牌：solarbio | 貨號(hào)：K106576P

英文名稱Anti-MDM2 Polyclonal Antibody
宿主Rabbit
別名ACTFS;hdm2;HDMX;E3 ubiquitin-protein ligase Mdm2
應(yīng)用WB
稀釋比例WB 1:3000.
交叉反應(yīng) Human Mouse Rat
蛋白分子量48kDa
Gene ID4193
保存Store at -20°C. Avoid freeze / thaw cycles.
儲(chǔ)存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原A synthetic peptide of human MDM2
性狀液體
Public Immunogen RangeA synthetic peptide of human MDM2
Subcellular LocationsNucleus
Swiss ProtQ00987
克隆類型 Polyclonal Antibody
背景資料Inhibits TP53/p53- and TP73/p73-mediated cell cyclearrest and apoptosis by binding its transcriptional activation domain. Functions as a ubiquitin ligase E3, in the presence of E1 and E2, toward p53 and itself. Permits the nuclear export of p53 and targets it for proteasome-mediated proteolysis. Binds p53, p73, ARF(P14), ribosomal protein L5 and specifically to RNA. Can interact also with retinoblastoma protein(RB), E1A-associated protein EP300 and the E2F1 transcription factor. Forms a ternary complex with TP53/p53 and WWOX.

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