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Anti-RPSAPolyclonalAntibody-一抗-抗體-蛋白與免疫

2023-10-29

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Anti-RPSA Polyclonal Antibody品牌:solarbio | 貨號(hào):K005986P

英文名稱(chēng)Anti-RPSA Polyclonal Antibody
宿主Rabbit
別名37LRP;67LR;ICAS;LAMBR;LAMR1;LBP;LBP/p40;LRP;LRP/LR;NEM/1CHD4;SA;lamR;p40
應(yīng)用WB
稀釋比例WB 1:500-2000.
交叉反應(yīng) Mouse
蛋白分子量33kDa
Gene ID3921
保存Store at -20°C. Avoid freeze / thaw cycles.
儲(chǔ)存液Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原Recombinant protein of human RPSA
性狀液體
Public Immunogen RangeRecombinant protein of human RPSA
Subcellular LocationsCell membrane Cytoplasm Nucleus
Swiss ProtP08865
克隆類(lèi)型 Polyclonal Antibody
背景資料Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

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