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Anti-Phospho-NFκBp105-S927PolyclonalAntibody-一抗-抗體-蛋白與免疫

2023-10-29

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Anti-Phospho-NFκB p105-S927 Polyclonal Antibody

英文名稱Rabbit Phospho-NFκB p105-S927 Polyclonal Antibody
應(yīng)用2 WB
克隆類型2 Polyclonal Antibody
別名CVID12;EBP-1;KBF1;NF-kB1;NF-kappa-B;NF-kappaB;NFKB-p105;NFKB-p50;NFkappaB;p105;p50
應(yīng)用WB
稀釋比例WB1:500-1:1000
交叉反應(yīng) Human
蛋白分子量105kDa
Gene ID4790
保存Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment.
儲(chǔ)存液PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原A phospho specific peptide corresponding to residues surrounding S927 of human NFκB p105
性狀Lyophilized or Liquid
Swiss ProtP19838
克隆類型 Polyclonal Antibody
來(lái)源 Rabbit
背景資料This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.

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