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Recombinant Mouse M-CSF巨噬細胞集落刺激因子

MCSF,

also known as CSF1,

is a fourαhelicalbundle

cytokine that is the primary regulator of macrophage survival, proliferation and differentiation （1 3）.

MCSF

is also essential for the survival and proliferation of osteoclast progenitors （1, 4）. MCSF

also primes and enhances macrophage killing of tumor cells and

microorganisms, regulates the release of cytokines and other inflammatory modulators from macrophages, and stimulates pinocytosis （2, 3）. MCSF

increases during

pregnancy to support implantation and growth of the decidua and placenta （5）. Sources of MCSF

include fibroblasts, activated macrophages, endometrial secretory

epithelium, bone marrow stromal cells and activated endothelial cells （1 5）.

The MCSF

receptor （cfms）

transduces its pleotropic effects and mediates its

endocytosis. MCSF

mRNAs of various sizes occur （3 9）.

Full length mouse MCSF

transcripts encode a 520 amino acid （aa） type I transmembrane （TM） protein with

a 462 aa extracellular region, a 21 aa TM domain, and a 37 aa cytoplasmic tail that forms a 140 kDa covalent dimer. Differential processing produces two

proteolytically cleaved, secreted dimers. One is an Nand

Oglycosylated

86 kDa dimer, while the other is modified by both glycosylation and chondroitinsulfate

proteoglycan （PG） to generate a 200 kDa subunit. Although PGmodified

MCSF

can circulate, it may be immobilized by attachment to type V collagen （8）. Shorter

transcripts encode M CSF

that lacks cleavage and PG sites and produces an Nglycosylated

68 kDa TM dimer and a slowly produced 44 kDa secreted dimer （7）.

Although forms may vary in activity and halflife,

all contain the Nterminal

150 aa portion that is necessary and sufficient for interaction with the M CSF

receptor

（10, 11）. The first 229 aa of mature mouse MCSF

shares 87%, 83%, 82% and 81% aa identity with corresponding regions of rat, dog, cow and human MCSF,

respectively （12, 13）. Human MCSF

is active in the mouse, but mouse MCSF

is reported to be speciesspecific

Recombinant Mouse M-CSF巨噬細胞集落刺激因子

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