RD TOCRIS一級代理，Z-Guggulsterone供應(yīng)CAS號39025-23-5
Catalog Number:3570
Chemical Name:(Z)-Pregna-4,17(20)-diene-3,16-dione
詳細(xì)產(chǎn)品信息：
Biological Activity
Broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Kivalues are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (Ki= 315 nM). Induces apoptosis in prostate cancer cells and inhibits angiogenesis via suppression of the VEGF-VEGFR2-Akt signaling pathway. Exhibits antilipidemic activity via antagonism of the farnesoid X receptor (FXR) and displays antiseptic, antirheumatic and anti-inflammatory activityin vivo. More active isomer ofguggulsterone(Cat. No. 2013).
Technical Data
M.Wt:
312.45
Formula:
C21H28O2
Solubility:
Soluble to 20 mM in DMSO with gentle warming and to 10 mM in ethanol with gentle warming
Purity:
>98%
Storage:
Store at RT
CAS No:
39025-23-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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